This page was published on May 10, 2015, modified on Nov 24, 2020 by Dr. Weiner (Dentist) of Envy Smile Dental Spa

Restylane/Perlane FAQ’s

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What is Restylane/Perlane®?

Restylane/Perlane is a safe and natural cosmetic dermal filler that restores volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds).

What is Restylane/Perlane® made of?

Restylane/Perlane is the first cosmetic dermal filler made of non-animal-based hyaluronic acid. Hyaluronic acid is a natural substance that already exists in the human body and is used to provide volume and fullness to the skin. The hyaluronic acid in Restylane/Perlane is a crystal-clear gel called NASHATM, or Non-Animal Stabilized Hyaluronic Acid. NASHA is biodegradable and fully biocompatible with human hyaluronic acid.

How is Restylane/Perlane® different than other hyaluronic acid-based products?

Unlike rooster-derived hyaluronic acid-based products, Restylane/Perlane is free from animal proteins. This quality limits the risk of animal-based disease transmission or allergic reaction. Restylane/Perlane contains trace amounts of gram-positive bacterial proteins and should not be used by patients with a history of allergies to such materials. Additionally, Restylane/Perlane lasts about six months.

Is Restylane/Perlane® safe?

Yes. Restylane/Perlane has been used by dermatologists and plastic surgeons since 1996 worldwide. There is limited risk of animal-based disease transmission or allergic reaction. Restylane/Perlane is fully biocompatible and allergy testing is not required.

Here are a few other things you’ll want to know. After your treatment, you might have some redness or swelling. This will normally last less than seven days. Sunbathing and cold outdoor activities should be avoided until any redness or swelling disappear. you should not be treated with Restylane/Perlane if you are pregnant, breastfeeding, or under 18.

Where can Restylane/Perlane® be used?

In the U.S. the FDA has approved Restylane/Perlane for facial wrinkles and folds like the ones from the nose to the corners of the mouth. Restylane/Perlane has been used in more then 3 million treatments in over 60 countries to correct a variety of wrinkles. Your doctor will consult with you prior to your injection regarding common treatment areas.

How long does Restylane/Perlane® last?

Restylane/Perlane is proven to deliver long-lasting results. Studies have shown that Restylane/Perlane effects generally last for about six months! Restylane/Perlane’s stabilization technology helps maintain the cosmetic effect until the injected material is nearly gone.

How often should I have Restylane/Perlane® treatments done?

Treatments are typically scheduled twice a year. Having a follow-up treatment before the product has fully dissipated may enhance the lasting effect.

What should patients do prior to treatment?

Restylane/Perlane requires no pretesting, but you should take a few precautions before being treated. Avoid using aspirin, non-steroidal anti-inflammatory medications, St. John’s Word, or high doses of Vitamin E supplements prior to treatment, because these may increase bruising or bleeding at the injection site. Also, if you have previously suffered from facial cold sores, discuss this with your physician. He/She may consider prescribing a medication to minimize recurrence.

How is Restylane/Perlane® different from Botox® Cosmetic?

Restylane/Perlane is a natural, cosmetic filler that plumps up the skin to smooth away facial wrinkles. In contrast, Botox Cosmetic is a drug that relaxes the muscles underlying wrinkles. Many patients have been very pleased after receiving treatment with both products in different areas of the face.

How is Restylane/Perlane® different from bovine collagen?

Bovine collagen is derived from animals (cows) and requires an allergy test with up to a three-week waiting period. Restylane/Perlane can be administered immediately—no waiting is required.

Do the injections hurt?

Restylane/Perlane is injected directly into the skin in tiny amounts by an ultrafine needle, resulting in minimal discomfort. The procedure is simple and convenient, and results are practically instantaneous. Some patients may experience discomfort around the injection site. To optimize your comfort during the short procedure your physician may anesthetize the treatment area.